Breast Milk Shows New Opportunities For Reducing Heart Damage Caused In Premature Birth -Researchers

Researchers have found that feeding premature babies breast milk could reduce heart damage caused by an early birth. Babies born before full-term – 37 weeks – are thought to have weaker hearts due to smaller chambers that help pump the blood.

But giving premature babies breast milk, instead of formula, could alleviate the problem, a review of evidence suggests. The researchers believe breast milk can help regulate hormones and growth factors and strengthen the infant’s immune system, reducing inflammation.

Premature babies are more likely to develop cardiovascular diseases as adults than their full term peers.
One of the long-term health complications young adults born prematurely may have is a unique heart characteristic.

These can include smaller heart chambers, relatively higher blood pressure and a disproportionate increase in muscle mass in the heart. Lead author Professor Afif El-Khuffash, a paediatrician at the Royal College of Surgeons in Ireland, said:

“It is becoming increasingly clear premature birth results in long term adverse cardiovascular effects with important clinical consequences. There is a distinct lack of preventative and therapeutic interventions available to alleviate those effects.”

His international team including colleagues at the University of Oxford and Harvard Medical School wrote their review of evidence in the journal Pediatric Research.

One study compared 30 preterm-born adults who were assigned only human milk during their hospital with 16 others exclusively fed formula.Is breast best?

Breast milk contains antibodies passed on from the mother, which boost a baby’s immune system and help it fight infections and viruses.There is also evidence that breastfed babies have higher IQs and are less at risk of obesity – because formula milk is higher in fat.

Breastfeeding is also deemed beneficial for the mother because it enables her to bond with the newborn.It also enables her to lose weight, as nursing mothers burn up to 500 calories a day extra. Mothers are urged to breastfeed, if possible, in order to give their infants the maximum dose of nutrients.

Bottle-feeding can be costly for many parents struggling to cope with the financial burden of a new baby.Formula milk also has varying levels of nutrients, decided by the provider. And it is often not easy for babies to digest.

However, babies who consume both breast milk and formula may not get enough vitamin D and still need drops or mothers who take supplements.Detailed cardiovascular examinations, including Magnetic Resonance Imaging (MRI) scans when they were aged 23 and 28, showed their heart chambers were smaller than normal.But the difference in size was less pronounced in the human milk group, suggesting a potentially protective effect for heart structure.

It is not clear exactly how the breast milk improves heart health, but scientists believe it may be to do with antibodies passed from the mother to baby, strengthening a premature baby’s weak immune system.

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They also said breast milk contains a high amount of growth factors, enzymes, antibodies, and stem cells that may directly help the heart grow, which are not found in infant formulas.

Prof El-Khuffash, who is also consultant neonatologist at The Rotunda Hospital, Dublin, said:

“The current evidence comes from observational studies and highlights the strong link between early breast milk administrations and improvement in long-term heart health, but it lacks concrete mechanistic explanations.”

Identifying the key components within breast milk that result in improved heart health could pave the way for better treatment. Added Prof El-Khuffash:

“More studies on the composition of breast milk could make clear exactly what causes these health benefits, which could in turn lead to better treatment options.”

His team is continuing to study the effects in very premature infants by using novel scans to measure heart function.They hope to demonstrate that early breast milk exposure in premature infants can lead to significant improvements in heart function over the first two years of age.

It also adds to the host of benefits of feeding babies ‘the natural way’ – providing the most vulnerable infants ‘the best start in life’.